Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses

Disulfide bonds play a crucial role in folding and structural stabilization of monoclonal antibodies (mAbs). Disulfide bond reduction may happen during the mAb manufacturing process, resulting in low molecular weight species and possible failure to meet product specifications. Although many mitigati...

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Detalhes bibliográficos
Main Authors: Peifeng Tang, Zhijun Tan, Vivekh Ehamparanathan, Tingwei Ren, Laurel Hoffman, Cheng Du, Yuanli Song, Li Tao, Angela Lewandowski, Sanchayita Ghose, Zheng Jian Li, Shijie Liu
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2020-01-01
Colecção:mAbs
Assuntos:
Monoclonal antibody
disulfide bond
redox/reduction/reoxidation
kinetic modeling
Acesso em linha:https://www.tandfonline.com/doi/10.1080/19420862.2020.1829336
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