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An intact interchain disulfide bond is required for the neurotoxicity of tetanus toxin.
Tetanus toxin is composed of a heavy chain (100 kDa) and a light chain (50 kDa) held together by a single interchain disulfide bridge. An additional intrachain disulfide is present in the carboxy-terminal part of the heavy chain. Reduction of the two disulfide bonds in tetanus toxin with both chemic...
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| Publicado no: | Infect Immun |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
1990
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC313786/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2254033/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.58.12.4136-4141.1990 |
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