An intact interchain disulfide bond is required for the neurotoxicity of tetanus toxin.

Tetanus toxin is composed of a heavy chain (100 kDa) and a light chain (50 kDa) held together by a single interchain disulfide bridge. An additional intrachain disulfide is present in the carboxy-terminal part of the heavy chain. Reduction of the two disulfide bonds in tetanus toxin with both chemic...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Schiavo, G, Papini, E, Genna, G, Montecucco, C
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1990
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC313786/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2254033/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.58.12.4136-4141.1990
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