On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies

Disulfide bond reduction, which commonly occurs during monoclonal antibody (mAb) manufacturing processes, can result in a drug substance with high levels of low molecular weight (LMW) species that may fail release specifications because the drug’s safety and the efficiency may be affected by the pre...

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Autors principals: Zhijun Tan, Vivekh Ehamparanathan, Tingwei Ren, Peifeng Tang, Laurel Hoffman, June Kuang, Peiran Liu, Chao Huang, Cheng Du, Li Tao, Letha Chemmalil, Angela Lewandowski, Sanchayita Ghose, Zheng Jian Li, Shijie Liu
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis Group 2020-01-01
Col·lecció:mAbs
Matèries:
Antibody
disulfide bond
redox/reduction/reoxidation
low molecular weight
Protein A chromatography
Accés en línia:https://www.tandfonline.com/doi/10.1080/19420862.2020.1829333
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