Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses

Disulfide bonds play a crucial role in folding and structural stabilization of monoclonal antibodies (mAbs). Disulfide bond reduction may happen during the mAb manufacturing process, resulting in low molecular weight species and possible failure to meet product specifications. Although many mitigati...

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Pubblicato in:MAbs
Autori principali: Tang, Peifeng, Tan, Zhijun, Ehamparanathan, Vivekh, Ren, Tingwei, Hoffman, Laurel, Du, Cheng, Song, Yuanli, Tao, Li, Lewandowski, Angela, Ghose, Sanchayita, Li, Zheng Jian, Liu, Shijie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577745/
https://ncbi.nlm.nih.gov/pubmed/33031716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1829336
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