Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics

Manufacturability of immunoglobulin G4 (IgG4) antibodies from the Chemistry, Manufacture, and Controls (CMC) perspective has received little attention during early drug discovery. Despite the success of protein engineering in improving antibody biophysical properties, a clear gap still exists betwee...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Chen, Zhiqiang, Qian, Yueming, Song, Yuanli, Xu, Xuankuo, Tao, Li, Mussa, Nesredin, Ghose, Sanchayita, Li, Zheng Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577236/
https://ncbi.nlm.nih.gov/pubmed/33044887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1829338
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