Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics

Manufacturability of immunoglobulin G4 (IgG4) antibodies from the Chemistry, Manufacture, and Controls (CMC) perspective has received little attention during early drug discovery. Despite the success of protein engineering in improving antibody biophysical properties, a clear gap still exists betwee...

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Bibliografische gegevens
Gepubliceerd in:MAbs
Hoofdauteurs: Chen, Zhiqiang, Qian, Yueming, Song, Yuanli, Xu, Xuankuo, Tao, Li, Mussa, Nesredin, Ghose, Sanchayita, Li, Zheng Jian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2020
Onderwerpen:
Short Communication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577236/
https://ncbi.nlm.nih.gov/pubmed/33044887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1829338
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