Autophagy is a major regulator of β-cell insulin homeostasis

AIMS/HYPOTHESIS: We studied the role of protein degradation pathways in the regulation of insulin production and secretion and hypothesized that autophagy regulates proinsulin degradation, thereby modulating β-cell function. METHODS: Proinsulin localization in autophagosomes was demonstrated by conf...

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Dades bibliogràfiques
Publicat a:Diabetologia
Autors principals: Riahi, Yael, Wikstrom, Jakob D., Bachar-Wikstrom, Etty, Polin, Nava, Zucker, Hava, Lee, Myung-Shik, Quan, Wenying, Haataja, Leena, Liu, Ming, Arvan, Peter, Cerasi, Erol, Leibowitz, Gil
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912938/
https://ncbi.nlm.nih.gov/pubmed/26831301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-016-3868-9
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