Genome-wide DNA methylation landscape defines specialization of regulatory T cells in tissues

Regulatory T cells (T(reg)) perform two distinct functions: they maintain self-tolerance and support organ homeostasis by differentiation into specialized tissue T(reg) cells. We now report that epigenetic modifications define molecular characteristics of tissue T(reg) cells. Tagmentation-based whol...

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Udgivet i:Nat Immunol
Main Authors: Delacher, Michael, Imbusch, Charles D., Weichenhan, Dieter, Breiling, Achim, Hotz-Wagenblatt, Agnes, Träger, Ulrike, Hofer, Ann-Cathrin, Kägebein, Danny, Wang, Qi, Frauhammer, Felix, Mallm, Jan-Philipp, Bauer, Katharina, Herrmann, Carl, Lang, Philipp, Brors, Benedikt, Plass, Christoph, Feuerer, Markus
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912503/
https://ncbi.nlm.nih.gov/pubmed/28783152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3799
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