Rbpj expression in regulatory T cells is critical for restraining T(H)2 responses

The transcriptional regulator Rbpj is involved in T-helper (T(H)) subset polarization, but its function in T(reg) cells remains unclear. Here we show that T(reg)-specific Rbpj deletion leads to splenomegaly and lymphadenopathy despite increased numbers of T(reg) cells with a polyclonal TCR repertoir...

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Udgivet i:Nat Commun
Main Authors: Delacher, Michael, Schmidl, Christian, Herzig, Yonatan, Breloer, Minka, Hartmann, Wiebke, Brunk, Fabian, Kägebein, Danny, Träger, Ulrike, Hofer, Ann-Cathrin, Bittner, Sebastian, Weichenhan, Dieter, Imbusch, Charles D., Hotz-Wagenblatt, Agnes, Hielscher, Thomas, Breiling, Achim, Federico, Giuseppina, Gröne, Hermann-Josef, Schmid, Roland M., Rehli, Michael, Abramson, Jakub, Feuerer, Markus
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6453958/
https://ncbi.nlm.nih.gov/pubmed/30962454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09276-w
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