Oxidative stress increases M(1)dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA

Reactive oxygen species (ROS) are formed in mitochondria during electron transport and energy generation. Elevated levels of ROS lead to increased amounts of mitochondrial DNA (mtDNA) damage. We report that levels of M(1)dG, a major endogenous peroxidation-derived DNA adduct, are 50–100-fold higher...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Wauchope, Orrette R, Mitchener, Michelle M, Beavers, William N, Galligan, James J, Camarillo, Jeannie M, Sanders, William D, Kingsley, Philip J, Shim, Ha-Na, Blackwell, Thomas, Luong, Thong, deCaestecker, Mark, Fessel, Joshua P, Marnett, Lawrence J
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
Assuntos:
Genome Integrity, Repair and Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909422/
https://ncbi.nlm.nih.gov/pubmed/29438559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky089
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