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Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M(1)dG

The biological aldehydes, malondialdehyde and base propenal, react with DNA to form a prevalent guanine adduct, M(1)dG. The exocyclic ring of M(1)dG opens to the acyclic N(2)-OPdG structure when paired with C but remains closed in single-stranded DNA or when mispaired with T. M(1)dG is a target of n...

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Hlavní autoři: Cline, Susan D., Lodeiro, M. Fernanda, Marnett, Lawrence J., Cameron, Craig E., Arnold, Jamie J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995074/
https://ncbi.nlm.nih.gov/pubmed/20671026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq656
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