Oxidative stress increases M(1)dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA

Reactive oxygen species (ROS) are formed in mitochondria during electron transport and energy generation. Elevated levels of ROS lead to increased amounts of mitochondrial DNA (mtDNA) damage. We report that levels of M(1)dG, a major endogenous peroxidation-derived DNA adduct, are 50–100-fold higher...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Wauchope, Orrette R, Mitchener, Michelle M, Beavers, William N, Galligan, James J, Camarillo, Jeannie M, Sanders, William D, Kingsley, Philip J, Shim, Ha-Na, Blackwell, Thomas, Luong, Thong, deCaestecker, Mark, Fessel, Joshua P, Marnett, Lawrence J
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909422/
https://ncbi.nlm.nih.gov/pubmed/29438559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky089
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