Oxidative stress increases M(1)dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA

Reactive oxygen species (ROS) are formed in mitochondria during electron transport and energy generation. Elevated levels of ROS lead to increased amounts of mitochondrial DNA (mtDNA) damage. We report that levels of M(1)dG, a major endogenous peroxidation-derived DNA adduct, are 50–100-fold higher...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Wauchope, Orrette R, Mitchener, Michelle M, Beavers, William N, Galligan, James J, Camarillo, Jeannie M, Sanders, William D, Kingsley, Philip J, Shim, Ha-Na, Blackwell, Thomas, Luong, Thong, deCaestecker, Mark, Fessel, Joshua P, Marnett, Lawrence J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909422/
https://ncbi.nlm.nih.gov/pubmed/29438559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky089
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