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In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M(1)dG
3-(2-Deoxy-β-d-erythro-pentofuranosyl)pyrimido[1,2-α]purin-10(3H)-one (M(1)dG) is a DNA adduct arising from the reaction of 2-deoxyguanosine with the lipid peroxidation product, malondialdehyde, or the DNA peroxidation product, base propenal. M(1)dG is mutagenic in bacteria and mammalian cells and i...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1458938/ https://ncbi.nlm.nih.gov/pubmed/16614064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602017103 |
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