In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M(1)dG

3-(2-Deoxy-β-d-erythro-pentofuranosyl)pyrimido[1,2-α]purin-10(3H)-one (M(1)dG) is a DNA adduct arising from the reaction of 2-deoxyguanosine with the lipid peroxidation product, malondialdehyde, or the DNA peroxidation product, base propenal. M(1)dG is mutagenic in bacteria and mammalian cells and i...

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Detalhes bibliográficos
Main Authors: Otteneder, Michael B., Knutson, Charles G., Daniels, J. Scott, Hashim, Muhammed, Crews, Brenda C., Remmel, Rory P., Wang, Hao, Rizzo, Carmelo, Marnett, Lawrence J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458938/
https://ncbi.nlm.nih.gov/pubmed/16614064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602017103
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