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Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M(1)dG
The biological aldehydes, malondialdehyde and base propenal, react with DNA to form a prevalent guanine adduct, M(1)dG. The exocyclic ring of M(1)dG opens to the acyclic N(2)-OPdG structure when paired with C but remains closed in single-stranded DNA or when mispaired with T. M(1)dG is a target of n...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2995074/ https://ncbi.nlm.nih.gov/pubmed/20671026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq656 |
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