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Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy
Class B peptide hormone GPCRs are targets for the treatment of major chronic disease. Peptide ligands of these receptors display biased agonism and this may provide future therapeutic advantage. Recent active structures of the calcitonin (CT) and glucagon-like peptide-1 (GLP-1) receptors reveal dist...
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| Pubblicato in: | Biochem Pharmacol |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier Science
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5908784/ https://ncbi.nlm.nih.gov/pubmed/29454620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2018.02.005 |
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