Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor

[Image: see text] Amylin is coexpressed with insulin in pancreatic islet β-cells and has potent effects on gastric emptying and food intake. The effect of amylin on satiation has been postulated to involve AMY(3) receptors (AMY(3)R) that are heteromers of the calcitonin receptor (CTR) and receptor a...

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Detalhes bibliográficos
Publicado no:ACS Pharmacol Transl Sci
Main Authors: Pham, Vi, Zhu, Yue, Dal Maso, Emma, Reynolds, Christopher A., Deganutti, Giuseppe, Atanasio, Silvia, Hick, Caroline A., Yang, Dehua, Christopoulos, Arthur, Hay, Debbie L., Furness, Sebastian G. B., Wang, Ming-Wei, Wootten, Denise, Sexton, Patrick M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7088965/
https://ncbi.nlm.nih.gov/pubmed/32219220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.9b00010
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