Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor

[Image: see text] Amylin is coexpressed with insulin in pancreatic islet β-cells and has potent effects on gastric emptying and food intake. The effect of amylin on satiation has been postulated to involve AMY(3) receptors (AMY(3)R) that are heteromers of the calcitonin receptor (CTR) and receptor a...

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Pubblicato in:ACS Pharmacol Transl Sci
Autori principali: Pham, Vi, Zhu, Yue, Dal Maso, Emma, Reynolds, Christopher A., Deganutti, Giuseppe, Atanasio, Silvia, Hick, Caroline A., Yang, Dehua, Christopoulos, Arthur, Hay, Debbie L., Furness, Sebastian G. B., Wang, Ming-Wei, Wootten, Denise, Sexton, Patrick M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2019
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7088965/
https://ncbi.nlm.nih.gov/pubmed/32219220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.9b00010
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