Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

Class B peptide hormone GPCRs are targets for the treatment of major chronic disease. Peptide ligands of these receptors display biased agonism and this may provide future therapeutic advantage. Recent active structures of the calcitonin (CT) and glucagon-like peptide-1 (GLP-1) receptors reveal dist...

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Udgivet i:Biochem Pharmacol
Main Authors: Dal Maso, Emma, Zhu, Yue, Pham, Vi, Reynolds, Christopher A., Deganutti, Giuseppe, Hick, Caroline A., Yang, Dehua, Christopoulos, Arthur, Hay, Debbie L., Wang, Ming-Wei, Sexton, Patrick M., Furness, Sebastian G.B., Wootten, Denise
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Science 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908784/
https://ncbi.nlm.nih.gov/pubmed/29454620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2018.02.005
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