An innovative high-throughput screening approach for discovery of small molecules that inhibit TNF Receptors

Tumor necrosis factor receptor 1 (TNFR1) is a transmembrane receptor that binds tumor necrosis factor or lymphotoxin-alpha and plays a critical role in regulating the inflammatory response. Upregulation of these ligands is associated with inflammatory and autoimmune diseases. Current treatments redu...

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Bibliographische Detailangaben
Veröffentlicht in:SLAS Discov
Hauptverfasser: Lo, Chih Hung, Vunnam, Nagamani, Lewis, Andrew K., Chiu, Ting-Lan, Brummel, Benjamin E., Schaaf, Tory M., Grant, Benjamin D., Bawaskar, Prachi, Thomas, David D., Sachs, Jonathan N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899890/
https://ncbi.nlm.nih.gov/pubmed/28530838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555217706478
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