Noncompetitive inhibitors of TNFR1 probe conformational activation states

Tumor necrosis factor receptor 1 (TNFR1) is a central mediator of the inflammatory pathway and is associated with several autoimmune diseases such as rheumatoid arthritis. A revision to the canonical model of TNFR1 activation suggests that activation involves conformational rearrangements of preasse...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Lo, Chih Hung, Schaaf, Tory M., Grant, Benjamin D., Lim, Colin Kin-Wye, Bawaskar, Prachi, Aldrich, Courtney C., Thomas, David D., Sachs, Jonathan N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008598/
https://ncbi.nlm.nih.gov/pubmed/31363069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aav5637
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