Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies

OBJECTIVE: Understanding the heterogeneous pathology in Alzheimer’s disease (AD) and related tauopathies is one of the most urgent and fundamental challenges facing the discovery of novel disease modifying therapies. Through monitoring ensembles of toxic and non-toxic tau oligomers spontaneously for...

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Bibliografiska uppgifter
I publikationen:Alzheimers Dement
Huvudupphovsmän: Lo, Chih Hung, Lim, Colin Kin-Wye, Ding, Zhipeng, Wickramasinghe, Sanjula P., Braun, Anthony R., Ashe, Karen H., Rhoades, Elizabeth, Thomas, David D., Sachs, Jonathan N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038631/
https://ncbi.nlm.nih.gov/pubmed/31653529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2019.06.4954
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