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Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies

OBJECTIVE: Understanding the heterogeneous pathology in Alzheimer’s disease (AD) and related tauopathies is one of the most urgent and fundamental challenges facing the discovery of novel disease modifying therapies. Through monitoring ensembles of toxic and non-toxic tau oligomers spontaneously for...

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Dades bibliogràfiques
Publicat a:Alzheimers Dement
Autors principals: Lo, Chih Hung, Lim, Colin Kin-Wye, Ding, Zhipeng, Wickramasinghe, Sanjula P., Braun, Anthony R., Ashe, Karen H., Rhoades, Elizabeth, Thomas, David D., Sachs, Jonathan N.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038631/
https://ncbi.nlm.nih.gov/pubmed/31653529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2019.06.4954
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