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Noncompetitive inhibitors of TNFR1 probe conformational activation states
Tumor necrosis factor receptor 1 (TNFR1) is a central mediator of the inflammatory pathway and is associated with several autoimmune diseases such as rheumatoid arthritis. A revision to the canonical model of TNFR1 activation suggests that activation involves conformational rearrangements of preasse...
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| Pubblicato in: | Sci Signal |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7008598/ https://ncbi.nlm.nih.gov/pubmed/31363069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aav5637 |
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