Structural basis for the ethanol action on G-protein–activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy

Ethanol consumption leads to a wide range of pharmacological effects by acting on the signaling proteins in the human nervous system, such as ion channels. Despite its familiarity and biological importance, very little is known about the molecular mechanisms underlying the ethanol action, due to ext...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Toyama, Yuki, Kano, Hanaho, Mase, Yoko, Yokogawa, Mariko, Osawa, Masanori, Shimada, Ichio
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2018
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899474/
https://ncbi.nlm.nih.gov/pubmed/29581303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722257115
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