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Structural basis for the ethanol action on G-protein–activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy

Ethanol consumption leads to a wide range of pharmacological effects by acting on the signaling proteins in the human nervous system, such as ion channels. Despite its familiarity and biological importance, very little is known about the molecular mechanisms underlying the ethanol action, due to ext...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Toyama, Yuki, Kano, Hanaho, Mase, Yoko, Yokogawa, Mariko, Osawa, Masanori, Shimada, Ichio
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899474/
https://ncbi.nlm.nih.gov/pubmed/29581303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722257115
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