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Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling
To accurately recapitulate the heterogeneity of human diseases, animal models require to recreate multiple complex genetic alterations. Here, we combine the RCAS-TVA system with the CRISPR-Cas9 genome editing tools for precise modeling of human tumors. We show that somatic deletion in neural stem ce...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5899147/ https://ncbi.nlm.nih.gov/pubmed/29654229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03731-w |
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