Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling

To accurately recapitulate the heterogeneity of human diseases, animal models require to recreate multiple complex genetic alterations. Here, we combine the RCAS-TVA system with the CRISPR-Cas9 genome editing tools for precise modeling of human tumors. We show that somatic deletion in neural stem ce...

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Publicat a:Nat Commun
Autors principals: Oldrini, Barbara, Curiel-García, Álvaro, Marques, Carolina, Matia, Veronica, Uluçkan, Özge, Graña-Castro, Osvaldo, Torres-Ruiz, Raul, Rodriguez-Perales, Sandra, Huse, Jason T., Squatrito, Massimo
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899147/
https://ncbi.nlm.nih.gov/pubmed/29654229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03731-w
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