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Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima

Most transcription factors (TFs) can bind to a population of sequences closely related to a single optimal site. However, some TFs can bind to two distinct sequences that represent two local optima in the Gibbs free energy of binding (ΔG). To determine the molecular mechanism behind this effect, we...

詳細記述

保存先:
書誌詳細
出版年:eLife
主要な著者: Morgunova, Ekaterina, Yin, Yimeng, Das, Pratyush K, Jolma, Arttu, Zhu, Fangjie, Popov, Alexander, Xu, You, Nilsson, Lennart, Taipale, Jussi
フォーマット: Artigo
言語:Inglês
出版事項: eLife Sciences Publications, Ltd 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896879/
https://ncbi.nlm.nih.gov/pubmed/29638214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32963
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