Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima

Most transcription factors (TFs) can bind to a population of sequences closely related to a single optimal site. However, some TFs can bind to two distinct sequences that represent two local optima in the Gibbs free energy of binding (ΔG). To determine the molecular mechanism behind this effect, we...

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Bibliographic Details
Published in:eLife
Main Authors: Morgunova, Ekaterina, Yin, Yimeng, Das, Pratyush K, Jolma, Arttu, Zhu, Fangjie, Popov, Alexander, Xu, You, Nilsson, Lennart, Taipale, Jussi
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2018
Subjects:
Biochemistry and Chemical Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896879/
https://ncbi.nlm.nih.gov/pubmed/29638214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32963
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