Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima

Most transcription factors (TFs) can bind to a population of sequences closely related to a single optimal site. However, some TFs can bind to two distinct sequences that represent two local optima in the Gibbs free energy of binding (ΔG). To determine the molecular mechanism behind this effect, we...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Morgunova, Ekaterina, Yin, Yimeng, Das, Pratyush K, Jolma, Arttu, Zhu, Fangjie, Popov, Alexander, Xu, You, Nilsson, Lennart, Taipale, Jussi
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896879/
https://ncbi.nlm.nih.gov/pubmed/29638214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32963
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