Bacterial Pore-Forming Toxins Promote the Activation of Caspases in Parallel to Necroptosis to Enhance Alarmin Release and Inflammation During Pneumonia

Pore-forming toxins are the most common virulence factor in pathogenic bacteria. They lead to membrane permeabilization and cell death. Herein, we show that respiratory epithelial cells (REC) undergoing bacterial pore-forming toxin (PFT)-induced necroptosis simultaneously experienced caspase activat...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Gonzalez-Juarbe, Norberto, Bradley, Kelley M., Riegler, Ashleigh N., Reyes, Luis F., Brissac, Terry, Park, Sang-Sang, Restrepo, Marcos I., Orihuela, Carlos J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895757/
https://ncbi.nlm.nih.gov/pubmed/29643440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24210-8
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