Inhibition of Necroptosis to Prevent Long-term Cardiac Damage During Pneumococcal Pneumonia and Invasive Disease

BACKGROUND: Streptococcus pneumoniae infection can result in bacteremia with devastating consequences including heart damage. Necroptosis is a proinflammatory form of cell death instigated by pore-forming toxins such as S. pneumoniae pneumolysin. Necroptosis-inhibiting drugs may lessen organ damage...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Beno, Sarah M, Riegler, Ashleigh N, Gilley, Ryan P, Brissac, Terry, Wang, Yong, Kruckow, Katherine L, Jadapalli, Jeevan K, Wright, Griffin M, Shenoy, Anukul T, Stoner, Sara N, Restrepo, Marcos I, Deshane, Jessy S, Halade, Ganesh V, González-Juarbe, Norberto, Orihuela, Carlos J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7896277/
https://ncbi.nlm.nih.gov/pubmed/32492702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiaa295
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