Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia

Necroptosis is a highly pro-inflammatory mode of cell death regulated by RIP (or RIPK)1 and RIP3 kinases and mediated by the effector MLKL. We report that diverse bacterial pathogens that produce a pore-forming toxin (PFT) induce necroptosis of macrophages and this can be blocked for protection agai...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: González-Juarbe, Norberto, Gilley, Ryan Paul, Hinojosa, Cecilia Anahí, Bradley, Kelley Margaret, Kamei, Akinobu, Gao, Geli, Dube, Peter Herman, Bergman, Molly Ann, Orihuela, Carlos Javier
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676650/
https://ncbi.nlm.nih.gov/pubmed/26659062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005337
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