Differential Pharmacology and Binding of mGlu(2) Receptor Allosteric Modulators

Allosteric modulation of metabotropic glutamate receptor 2 (mGlu(2)) has demonstrated efficacy in preclinical rodent models of several brain disorders, leading to industry and academic drug discovery efforts. Although the pharmacology and binding sites of some mGlu(2) allosteric modulators have been...

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Pubblicato in:Mol Pharmacol
Autori principali: O’Brien, Daniel E., Shaw, Douglas M., Cho, Hyekyung P., Cross, Alan J., Wesolowski, Steven S., Felts, Andrew S., Bergare, Jonas, Elmore, Charles S., Lindsley, Craig W., Niswender, Colleen M., Conn, P. Jeffrey
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894801/
https://ncbi.nlm.nih.gov/pubmed/29545267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.110114
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