Functional anti-TIGIT antibodies regulate development of autoimmunity and anti-tumor immunity

Co-inhibitory receptors, such as CTLA-4 and PD-1, play a critical role in maintaining immune homeostasis by dampening T cell responses. Recently, they have gained attention as therapeutic targets in chronic disease settings where their dysregulated expression contributes to suppressed immune respons...

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Detaylı Bibliyografya
Yayımlandı:J Immunol
Asıl Yazarlar: Dixon, Karen O., Schorer, Michelle, Nevin, James, Etminan, Yassaman, Amoozgar, Zohreh, Kondo, Takaaki, Kurtulus, Sema, Kassam, Nasim, Sobel, Raymond A., Fukumura, Dai, Jain, Rakesh K., Anderson, Ana C., Kuchroo, Vijay K., Joller, Nicole
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893394/
https://ncbi.nlm.nih.gov/pubmed/29500245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700407
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