Functional anti-TIGIT antibodies regulate development of autoimmunity and anti-tumor immunity

Co-inhibitory receptors, such as CTLA-4 and PD-1, play a critical role in maintaining immune homeostasis by dampening T cell responses. Recently, they have gained attention as therapeutic targets in chronic disease settings where their dysregulated expression contributes to suppressed immune respons...

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Опубликовано в: :J Immunol
Главные авторы: Dixon, Karen O., Schorer, Michelle, Nevin, James, Etminan, Yassaman, Amoozgar, Zohreh, Kondo, Takaaki, Kurtulus, Sema, Kassam, Nasim, Sobel, Raymond A., Fukumura, Dai, Jain, Rakesh K., Anderson, Ana C., Kuchroo, Vijay K., Joller, Nicole
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893394/
https://ncbi.nlm.nih.gov/pubmed/29500245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700407
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