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Functional anti-TIGIT antibodies regulate development of autoimmunity and anti-tumor immunity
Co-inhibitory receptors, such as CTLA-4 and PD-1, play a critical role in maintaining immune homeostasis by dampening T cell responses. Recently, they have gained attention as therapeutic targets in chronic disease settings where their dysregulated expression contributes to suppressed immune respons...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5893394/ https://ncbi.nlm.nih.gov/pubmed/29500245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700407 |
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