Functional anti-TIGIT antibodies regulate development of autoimmunity and anti-tumor immunity

Co-inhibitory receptors, such as CTLA-4 and PD-1, play a critical role in maintaining immune homeostasis by dampening T cell responses. Recently, they have gained attention as therapeutic targets in chronic disease settings where their dysregulated expression contributes to suppressed immune respons...

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Udgivet i:J Immunol
Main Authors: Dixon, Karen O., Schorer, Michelle, Nevin, James, Etminan, Yassaman, Amoozgar, Zohreh, Kondo, Takaaki, Kurtulus, Sema, Kassam, Nasim, Sobel, Raymond A., Fukumura, Dai, Jain, Rakesh K., Anderson, Ana C., Kuchroo, Vijay K., Joller, Nicole
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893394/
https://ncbi.nlm.nih.gov/pubmed/29500245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700407
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