Functional anti-TIGIT antibodies regulate development of autoimmunity and anti-tumor immunity

Co-inhibitory receptors, such as CTLA-4 and PD-1, play a critical role in maintaining immune homeostasis by dampening T cell responses. Recently, they have gained attention as therapeutic targets in chronic disease settings where their dysregulated expression contributes to suppressed immune respons...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Dixon, Karen O., Schorer, Michelle, Nevin, James, Etminan, Yassaman, Amoozgar, Zohreh, Kondo, Takaaki, Kurtulus, Sema, Kassam, Nasim, Sobel, Raymond A., Fukumura, Dai, Jain, Rakesh K., Anderson, Ana C., Kuchroo, Vijay K., Joller, Nicole
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893394/
https://ncbi.nlm.nih.gov/pubmed/29500245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700407
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