TIGIT predominantly regulates the immune response via regulatory T cells

Coinhibitory receptors are critical for the maintenance of immune homeostasis. Upregulation of these receptors on effector T cells terminates T cell responses, while their expression on Tregs promotes their suppressor function. Understanding the function of coinhibitory receptors in effector T cells...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Kurtulus, Sema, Sakuishi, Kaori, Ngiow, Shin-Foong, Joller, Nicole, Tan, Dewar J., Teng, Michele W.L., Smyth, Mark J., Kuchroo, Vijay K., Anderson, Ana C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4639980/
https://ncbi.nlm.nih.gov/pubmed/26413872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81187
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