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Lag-3, Tim-3, and TIGIT co-inhibitory receptors with specialized functions in immune regulation

Co-inhibitory receptors, such as CTLA-4 and PD-1, have an important role in regulating T cell responses and have proven to be effective targets in the setting of chronic diseases where constitutive co-inhibitory receptor expression on T cells dampens effector T cell responses. Unfortunately, many pa...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Immunity
Hauptverfasser: Anderson, Ana C., Joller, Nicole, Kuchroo, Vijay K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942846/
https://ncbi.nlm.nih.gov/pubmed/27192565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.05.001
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