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Lag-3, Tim-3, and TIGIT co-inhibitory receptors with specialized functions in immune regulation
Co-inhibitory receptors, such as CTLA-4 and PD-1, have an important role in regulating T cell responses and have proven to be effective targets in the setting of chronic diseases where constitutive co-inhibitory receptor expression on T cells dampens effector T cell responses. Unfortunately, many pa...
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| Veröffentlicht in: | Immunity |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4942846/ https://ncbi.nlm.nih.gov/pubmed/27192565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.05.001 |
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