Checkpoint Receptor TIGIT Expressed on Tim-1(+) B Cells Regulates Tissue Inflammation

Tim-1, a phosphatidylserine receptor expressed on B cells, induces interleukin 10 (IL-10) production by sensing apoptotic cells. Here we show that mice with B cell-specific Tim-1 deletion develop tissue inflammation in multiple organs including spontaneous paralysis with inflammation in the central...

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發表在:Cell Rep
Main Authors: Xiao, Sheng, Bod, Lloyd, Pochet, Nathalie, Kota, Savithri Balasubramanian, Hu, Dan, Madi, Asaf, Kilpatrick, Jessica, Shi, Jingwen, Ho, Allen, Zhang, Huiyuan, Sobel, Raymond, Weiner, Howard L., Strom, Terry B., Quintana, Francisco J., Joller, Nicole, Kuchroo, Vijay K.
格式: Artigo
語言:Inglês
出版: 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496220/
https://ncbi.nlm.nih.gov/pubmed/32668241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107892
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