Checkpoint Receptor TIGIT Expressed on Tim-1(+) B Cells Regulates Tissue Inflammation

Tim-1, a phosphatidylserine receptor expressed on B cells, induces interleukin 10 (IL-10) production by sensing apoptotic cells. Here we show that mice with B cell-specific Tim-1 deletion develop tissue inflammation in multiple organs including spontaneous paralysis with inflammation in the central...

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Библиографические подробности
Опубликовано в: :Cell Rep
Главные авторы: Xiao, Sheng, Bod, Lloyd, Pochet, Nathalie, Kota, Savithri Balasubramanian, Hu, Dan, Madi, Asaf, Kilpatrick, Jessica, Shi, Jingwen, Ho, Allen, Zhang, Huiyuan, Sobel, Raymond, Weiner, Howard L., Strom, Terry B., Quintana, Francisco J., Joller, Nicole, Kuchroo, Vijay K.
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496220/
https://ncbi.nlm.nih.gov/pubmed/32668241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107892
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