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The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity

Co-inhibitory receptors are important regulators of T-cell function that define the balance between tolerance and autoimmunity. The immune regulatory function of co-inhibitory receptors, including CTLA-4, PD-1, TIM-3, TIGIT, and LAG-3, was first discovered in the setting of autoimmune disease models...

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Bibliografiske detaljer
Udgivet i:Cell Res
Main Authors: Schnell, Alexandra, Bod, Lloyd, Madi, Asaf, Kuchroo, Vijay K.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Singapore 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7118128/
https://ncbi.nlm.nih.gov/pubmed/31974523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-020-0277-x
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