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TIM3(+)FOXP3(+) regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer
T-cell immunoglobulin mucin 3 (TIM3) is an inhibitory molecule that has emerged as a key regulator of dysfunctional or exhausted CD8(+) T cells arising in chronic diseases such as cancer. In addition to exhausted CD8(+) T cells, highly suppressive regulatory T cells (Tregs) represent a significant b...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3654601/ https://ncbi.nlm.nih.gov/pubmed/23734331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.23849 |
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