TIM3(+)FOXP3(+) regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer

T-cell immunoglobulin mucin 3 (TIM3) is an inhibitory molecule that has emerged as a key regulator of dysfunctional or exhausted CD8(+) T cells arising in chronic diseases such as cancer. In addition to exhausted CD8(+) T cells, highly suppressive regulatory T cells (Tregs) represent a significant b...

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Bibliografiske detaljer
Main Authors: Sakuishi, Kaori, Ngiow, Shin Foong, Sullivan, Jenna M., Teng, Michele W. L., Kuchroo, Vijay K., Smyth, Mark J., Anderson, Ana C.
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2013
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654601/
https://ncbi.nlm.nih.gov/pubmed/23734331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.23849
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