A public antibody lineage that potently inhibits malaria infection by dual binding to the circumsporozoite protein

Immunization with attenuated Plasmodium falciparum sporozoites (PfSPZ) has been shown to be protective, but the features of the antibody response induced by this treatment remain unclear. To investigate this response at high resolution, we isolated IgM and IgG monoclonal antibodies from Tanzanian vo...

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Publicado en:Nat Med
Main Authors: Tan, Joshua, Sack, Brandon K, Oyen, David, Zenklusen, Isabelle, Piccoli, Luca, Barbieri, Sonia, Foglierini, Mathilde, Fregni, Chiara Silacci, Marcandalli, Jessica, Jongo, Said, Abdulla, Salim, Perez, Laurent, Corradin, Giampietro, Varani, Luca, Sallusto, Federica, Sim, B Kim Lee, Hoffman, Stephen L, Kappe, Stefan H I, Daubenberger, Claudia, Wilson, Ian A, Lanzavecchia, Antonio
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893353/
https://ncbi.nlm.nih.gov/pubmed/29554084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4513
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