Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis

Pulmonary alveolar proteinosis (PAP) is a severe autoimmune disease caused by autoantibodies that neutralize GM-CSF resulting in impaired function of alveolar macrophages. In this study, we characterize 21 GM-CSF autoantibodies from PAP patients and find that somatic mutations critically determine t...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Piccoli, Luca, Campo, Ilaria, Fregni, Chiara Silacci, Rodriguez, Blanca Maria Fernandez, Minola, Andrea, Sallusto, Federica, Luisetti, Maurizio, Corti, Davide, Lanzavecchia, Antonio
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477037/
https://ncbi.nlm.nih.gov/pubmed/26077231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8375
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