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Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis
Pulmonary alveolar proteinosis (PAP) is a severe autoimmune disease caused by autoantibodies that neutralize GM-CSF resulting in impaired function of alveolar macrophages. In this study, we characterize 21 GM-CSF autoantibodies from PAP patients and find that somatic mutations critically determine t...
Shranjeno v:
| izdano v: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Pub. Group
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4477037/ https://ncbi.nlm.nih.gov/pubmed/26077231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8375 |
| Oznake: |
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