A public antibody lineage that potently inhibits malaria infection by dual binding to the circumsporozoite protein

Immunization with attenuated Plasmodium falciparum sporozoites (PfSPZ) has been shown to be protective, but the features of the antibody response induced by this treatment remain unclear. To investigate this response at high resolution, we isolated IgM and IgG monoclonal antibodies from Tanzanian vo...

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Publicat a:Nat Med
Autors principals: Tan, Joshua, Sack, Brandon K, Oyen, David, Zenklusen, Isabelle, Piccoli, Luca, Barbieri, Sonia, Foglierini, Mathilde, Fregni, Chiara Silacci, Marcandalli, Jessica, Jongo, Said, Abdulla, Salim, Perez, Laurent, Corradin, Giampietro, Varani, Luca, Sallusto, Federica, Sim, B Kim Lee, Hoffman, Stephen L, Kappe, Stefan H I, Daubenberger, Claudia, Wilson, Ian A, Lanzavecchia, Antonio
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893353/
https://ncbi.nlm.nih.gov/pubmed/29554084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4513
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