Coupling of sterically demanding peptides by β-thiolactone-mediated native chemical ligation

The ligation of sterically demanding peptidyl sites such as those involving Val–Val and Val–Pro linkages has proven to be extremely challenging with conventional NCL methods that rely on exogenous thiol additives. Herein, we report an efficient β-thiolactone-mediated additive-free NCL protocol that...

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Veröffentlicht in:Chem Sci
Hauptverfasser: Chen, Huan, Xiao, Yunxian, Yuan, Ning, Weng, Jiaping, Gao, Pengcheng, Breindel, Leonard, Shekhtman, Alexander, Zhang, Qiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2018
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892351/
https://ncbi.nlm.nih.gov/pubmed/29675245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc04744d
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