Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation

Cell penetrating peptides (CPPs) are being increasingly used as efficient vectors for intracellular delivery of biologically active agents, such as therapeutic antisense oligonucleotides (ASOs). Unfortunately, ASOs have poor cell membrane permeability. The conjugation of ASOs to CPPs have been shown...

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Bibliografiske detaljer
Udgivet i:Front Chem
Main Authors: Dastpeyman, Mohadeseh, Karas, John A., Amin, Azin, Turner, Bradley J., Shabanpoor, Fazel
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7962911/
https://ncbi.nlm.nih.gov/pubmed/33738276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2021.627329
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